Publications
2018
Contribution of Vesicular Glutamate Transporters to Stress Response and Related Psychopathologies: Studies in VGluT3 Knockout Mice. Horvath HR, Fazekas CL, Balazsfi D, Jain SK, Haller J, Zelena D
Cellular and Molecular Neurobiology (2018 Jan;38(1):37-52)
DOI | PubMed
Social Learning Requires Plasticity Enhanced by Fluoxetine Through Prefrontal Bdnf-TrkB Signaling to Limit Aggression Induced by Post-Weaning Social Isolation. Mikics E, Guirado R, Umemori J, Toth M, Biro L, Miskolczi C, Balazsfi D, Zelena D, Castren E, Haller J, Karpova NN
Neuropsychopharmacology (2018 Jan;43(2):235-245.)
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Higher susceptibility of somatostatin 4 receptor gene-deleted mice to chronic stress-induced behavioral and neuroendocrine alterations. Scheich B, Cseko K, Borbely E, Abraham I, Csernus V, Gaszner B, Helyes Z
Neuroscience (2017 Mar 27;346:320-336.)
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Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia. Kovács G, Környei Z, Tóth K, Baranyi M, Brunner J, Neubrandt M, Dénes Á, Sperlágh B
Cell Calcium (2018 Jul 30;75:1-13.)
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Rapid non-classical effects of steroids on the membrane receptor dynamics and downstream signaling in neurons. Barabás K, Godó S, Lengyel F, Ernszt D, Pál J, Ábrahám IM
Hormones and Behavior ( 2018 May 19. pii: S0018-506X(18)30090-4.)
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The Role of Interleukin-10 in Mediating the Effect of Immune Challenge on Mouse Gonadotropin-Releasing Hormone Neurons In Vivo Barabás K, Barad Z, Dénes Á, Bhattarai JP, Han SK, Kiss E, Sármay G, Ábrahám IM
eNeuro (2018 Oct 15;5(5))
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2017
Dynamic changes in binding interaction networks of sex steroids establish their non-classical effects. Bálint M, Jeszenői N, Horváth I, Ábrahám IM, Hetényi Cs
Scientific Reports (2017 Nov 1;7(1):14847)
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Estradiol sensitizes the Transient Receptor Potential Vanilloid 1 receptor in pain responses Payrits M, Sághy É, Csekő K, Pohóczky K, Bölcskei K, Ernszt D, Barabás K, Szolcsányi J, Ábrahám IM, Helyes Zs, Szőke É
Endocrinology (2017 Oct 1;158(10):3249-3258.)
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Identifying non-toxic doses of manganese for manganese-enhanced magnetic resonance imaging to map brain areas activated by operant behavior in trained rats. Galosi R, Szalay C, Aradi M, Perlaki G, Pal J, Steier R, Lenard L, Karadi Z
Magnetic Resonance Imaging (2017 Apr;37:122-133.)
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ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex Beamer E, Kovács G, Sperlágh B
Brain Research Bulletin (2017 Oct;135:129-142.)
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Monitoring of Venus transgenic cell migration during pregnancy in non-transgenic rabbits Liptak N, Hoffmann OI, Kerekes A, Iski G, Ernszt D, Kvell K, Hiripi L, Bosze Z
Transgenic Research (2017 Apr;26(2):291-299)
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Estradiol sensitizes the Transient Receptor Potential Vanilloid 1 receptor in pain responses. Payrits M, Sághy É, Csekő K, Pohóczky K, Bölcskei K, Ernszt D, Barabás K, Szolcsányi J, Ábrahám IM, Helyes Zs, Szőke É
Endocrinology (2017 Oct 1;158(10):3249-3258)
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Median raphe region stimulation alone generates remote, but not recent fear memory traces. Balazsfi DG, Zelena D, Farkas L, Demeter K, Barna I, Cserep C, Takacs VT, Nyiri G, Goloncser F, Sperlagh B, Freund TF, Haller J
PLoS One (2017 Jul 14;12(7):e0181264.)
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Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice. Goloncser F, Baranyi M, Balazsfi D, Demeter K, Haller J, Freund TFF, Zelena D, Sperlagh B
Frontiers in Molecular Neuroscience ( 2017 Oct 12;10:325)
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Considerations for the use of virally delivered genetic tools for in-vivo circuit analysis and behavior in mutant mice: a practical guide to optogenetics. Zelena D, Demeter K, Haller J, Balazsfi D
Behavioural Pharmacology (2017 Dec;28(8):598-609)
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2016
Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models. Scheich B, Gaszner B, Kormos V, Laszlo K, Adori C, Borbely E, Hajna Z, Tekus V, Bolcskei K, Abraham I, Pinter E, Szolcsanyi J, Helyes Z,
Neuropharmacology (2016 Feb;101:204-15.)
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Treatment of beta amyloid 1-42 (Abeta1-42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo. Kwakowsky A, Potapov K, Kim S, Peppercorn K, Tate WP, Abraham IM
Scientific Reports ( 2016 Feb 16;6:21101)
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In vivo detection of hyperacute neuronal compaction and recovery by MRI following electric trauma in rats. Toth A, Katai E, Kalman E, Bogner P, Schwarcz A, Doczi T, Sik A, Pal J
Journal of Magnetic Resonance Imaging ( 2016 Oct;44(4):814-22)
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Oxidative stress induces transient O-GlcNAc elevation and tau dephosphorylation in SH-SY5Y cells. Katai E, Pal J, Poor VS, Purewal R, Miseta A, Nagy T
Journal of Cellular and Molecular Medicine ( 2016 Dec;20(12):2269-2277.)
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The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages. Dulk M, Kudlik G, Fekete A, Ernszt D, Kvell K, Pongracz JE, Mero BL, Szeder B, Radnai L, Geiszt M, Csecsy DE, Kovacs T, Uher F, Lanyi A, Vas V, Buday L
Scientific Reports (2016 Oct 6;6:34280)
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Possible contribution of epigenetic changes in the development of schizophrenia-like behavior in vasopressin-deficient Brattleboro rats. Demeter K, Török B, Fodor A, Varga J, Ferenczi S, Kovács KJ, Eszik I, Szegedi V, Zelena D
Behavioural Brain Research ( 2016 Mar 1;300:123-34.)
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Dissociation of adrenocorticotropin and corticosterone as well as aldosterone secretion during stress of hypoglycemia in vasopressin-deficient rats. Varga J, Ferenczi S, Kovacs KJ, Csano A, Prokopova B, Jezova D, Zelena D
Life Sciences (2016 Dec 1;166:66-74.)
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Enduring abolishment of remote but not recent expression of conditioned fear by the blockade of calcium-permeable AMPA receptors before extinction training. Zelena D, Mikics É, Balázsfi D , János Varga, Klausz B, Urbán E, Sipos E, Biró L, Miskolczi C, Kovács K, Ferenczi S, Haller J
Psychopharmacology (2016 Jun;233(11):2065-76.)
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Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models. Scheich B, Gaszner B, Kormos V, Laszlo K, Adori C, Borbely E, Hajna Z, Tekus V, Bolcskei K, Abraham I, Pinter E, Szolcsanyi J, Helyes Z,
Neuropharmacology. (2016 Feb;101:204-15.)
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Sex-dependent role of vesicular glutamate transporter 3 in stress-regulation and related anxiety phenotype during the early postnatal period. Balazsfi D, Farkas L, Csikota P, Fodor A, Zsebok S, Haller J, Zelena D
Stress- The International Journal on the Biology of Stress ( 2016 Jul;19(4):434-8.)
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Vasopressinergic control of stress-related behavior: studies in Brattleboro rats. Csikota P, Fodor A, Balazsfi D, Pinter O, Mizukami H, Weger S, Heilbronn R, Engelmann M, Zelena D
Stress- The International Journal on the Biology of Stress (2016 Jul;19(4):349-61)
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Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats. Fodor A, Kovacs KB, Balazsfi D, Klausz B, Pinter O, Demeter K, Daviu N, Rabasa C, Rotllant D, Nadal R, Zelena D
Physiology & Behavior (2016 May 1;158:100-11.)
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2015
Estradiol Modulation of Neurotrophin Receptor Expression in Female Mouse Basal Forebrain Cholinergic Neurons in vivo. Milne MR, Haug CA, Abraham IM, Kwakowsky A
Endocrinology ( 2015 Feb;156(2):613-26)
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Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. Simonin C, Awale M, Brand M, van Deursen R, Schwartz J, Fine M, Kovacs G, Hafliger P, Gyimesi G, Sithampari A, Charles RP, Hediger MA, Reymond JL
Angewandte-Chemie International Edition (2015 Dec 1;54(49):14748-52.)
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Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats. Balazsfi D, Pinter O, Klausz B, Kovacs KB, Fodor A, Torok B, Engelmann M, Zelena D
Psychoneuroendocrinology (2015 Jan;51:11-23.)
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Anxiogenic role of vasopressin during the early postnatal period: maternal separation-induced ultrasound vocalization in vasopressin-deficient Brattleboro rats. Varga J, Fodor A, Klausz B, Zelena D
Amino Acids (2015 Nov;47(11):2409-18)
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Vasopressin deficiency diminishes acute and long-term consequences of maternal deprivation in male rat pups. Zelena D, Stocker B, Barna I, Toth ZE, Makara GB
Psychoneuroendocrinology (2015 Jan;51:378-91.)
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Vasopressin signaling at brain level controls stress hormone release: the vasopressin-deficient Brattleboro rat as a model. Zelena D, Pinter O, Balazsfi DG, Langnaese K, Richter K, Landgraf R, Makara GB, Engelmann M
Amino Acids (2015 Nov;47(11):2245-53.)
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The janus face of stress on reproduction: from health to disease. Zelena D
International Journal of Endocrinology (2015;2015:458129.)
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2014
Effects of Neuron-Specific Estrogen Receptor (ER) α and ERβ Deletion on the Acute Estrogen Negative Feedback Mechanism in Adult Female Mice. Cheong RY, Porteous R, Chambon P, Ábrahám I, Herbison AE
Endocrinology (2014 Apr;155(4):1418-27)
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Non-classical effects of estradiol on cAMP responsive element binding protein phosphorylation in gonadotropin-releasing hormone neurons: mechanisms and role. Kwakowsky A, Cheong RY, Herbison AE, Abraham IM
Frontiers in Neuroendocrinology (2014 Jan;35(1):31-41.)
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Changes of PACAP level in cerebrospinal fluid and plasma of patients with severe traumatic brain injury. Bukovics P, Czeiter E, Amrein K, Kovacs N, Pal J, Tamas A, Bagoly T, Helyes Z, Buki A, Reglodi D
Peptides (2014 Oct;60:18-22)
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Development of the First Fluorescence Screening Assay for the SLC39A2 Zinc Transporter Franz Marie-Christine, Simonin Alexandre, Graeter Stefanie, Hediger Matthias A, Kovacs Gergely
Journal of Biomolecular Screening (2014 Jul;19(6):909-16.)
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Development and Validation of a Fast and Homogeneous Cell-Based Fluorescence Screening Assay for Divalent Metal Transporter 1 (DMT1/SLC11A2) Using the FLIPR Tetra Montalbetti Nicolas, Simonin Alexandre, Dalghi Marianela G, Kovacs Gergely, Hediger Matthias A
Journal of Biomolecular Screening (2014 Jul;19(6):900-8)
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Alteration in the Wnt microenvironment directly regulates molecular events leading to pulmonary senescence. Kovacs T, Csongei V, Feller D, Ernszt D, Smuk G, Sarosi V, Jakab L, Kvell K, Bartis D, Pongracz JE
Aging Cell (2014 Oct;13(5):838-49)
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The effects of lactation on impulsive behavior in vasopressin-deficient Brattleboro rats. Aliczki M, Fodor A, Balogh Z, Haller J, Zelena D
Hormones and Behavior (2014 Aug;66(3):545-51.)
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A wider view on gastric erosion: detailed evaluation of complex somatic and behavioral changes in rats treated with indomethacin at gastric ulcerogenic dose. Filaretova LP, Bagaeva TR, Morozova OY, Zelena D
Endocrine Regulations (2014 Oct;48(4):163-72.)
PubMed
Behavioral effects of perinatal opioid exposure. Fodor A, Timar J, Zelena D
Life Sciences (2014 May 28;104(1-2):1-8.)
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The effects of vasopressin deficiency on aggression and impulsiveness in male and female rats. Fodor A, Barsvari B, Aliczki M, Balogh Z, Zelena D, Goldberg SR, Haller J
Psychoneuroendocrinology (2014 Sep;47:141-50.)
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The Effect of Maternal Stress Activation on the Offspring during Lactation in Light of Vasopressin. Fodor Anna, Zelena Dora
Scientific World Journal ( 2014 Jan 14;2014:265394.)
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Sex-dependent effects of an early life treatment in rats that increases maternal care: vulnerability or resilience? Fuentes S, Daviu N, Gagliano H, Garrido P, Zelena D, Monasterio N, Armario A, Nadal R
Frontiers in Behavioral Neuroscience (2014 Feb 25;8:56.)
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Early life adversity and serotonin transporter gene variation interact at the level of the adrenal gland to affect the adult hypothalamo-pituitary-adrenal axis. van der Doelen RH, Deschamps W, D'Annibale C, Peeters D, Wevers RA, Zelena D, Homberg JR, Kozicz T
Translational Psychiatry (2014 Jul 8;4:e409)
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Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat. Varga J, Klausz B, Domokos A, Kalman S, Pakaski M, Szucs S, Garab D, Zvara A, Puskas L, Kalman J, Timar J, Bagdy G, Zelena D
Brain Research Bulletin (2014 Jan;100:6-13.)
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2013
Genistein Excitation of Gonadotrophin-Releasing Hormone Neurones in Juvenile Female Mice Bhattarai JP, Abraham IM, Han SK
Journal of Neuroendocrinology (2013 May;25(5):497-505.)
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Tracking of Single Receptor Molecule Mobility in Neuronal Membranes: A Quick Theoretical and Practical Guide Kwakowsky A, Potapov D, Abraham IM
Journal of Neuroendocrinology (2013 Nov;25(11):1231-7.)
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Neuroprotective Effects of Non-Classical Estrogen-Like Signaling Activators: From Mechanism to Potential Implications. Kwakowsky A, Koszegi Z, Cheong RY, Abraham IM
CNS & Neurological Disorders-Drug Targets (2013 Dec;12(8):1219-25.)
PubMed
Investigation of the inhibitory effects of the benzodiazepine derivative, 5-BDBD on P2X4 purinergic receptors by two complementary methods. Bernadett Balázs, Tamás Dankó, Gergely Kovács, László Köles, Matthias A Hediger, Ákos Zsembery
Cellular Physiology and Biochemistry (2013;32(1):11-24. )
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Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells. Deisl C, Simonin A, Anderegg M, Albano G, Kovacs G, Ackermann D, Moch H, Dolci W, Thorens B, Hediger MA, Fuster DG
Proceedings of the National Academy of Sciences of the United States of America (2013 Jun 11;110(24):10004-9.)
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Zinc transporters in prostate cancer. Franz M-C, Anderle P, Bürzle M, Suzuki Y, Freeman MR, Hediger MA, Kovacs G
Molecular Aspects of Medicine (2013 Apr-Jun;34(2-3):735-41.)
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Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Hofer A, Kovacs G, Zappatini A, Leuenberger M, Hediger MA, Lochner M
Bioorganic & Medicinal Chemistry ( 2013 Jun 1;21(11):3202-13.)
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Human TRPV5 and TRPV6: Key players in cadmium and zinc toxicity. Kovacs G, Montalbetti N, Franz M-C, Graeter S, Simonin A, Hediger MA
Cell Calcium (2013 Oct;54(4):276-86.)
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Mammalian iron transporters: Families SLC11 and SLC40. Montalbetti N, Simonin A, Kovacs G, Hediger MA
Molecular Aspects of Medicine (2013 Apr-Jun;34(2-3):270-87.)
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Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice. Aliczki M, Zelena D, Mikics E, Varga ZK, Pinter O, Bakos NV, Varga J, Haller J
Hormones and Behavior (2013 May;63(5):752-8.)
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Food-intake regulation during stress by the hypothalamo-pituitary-adrenal axis. Bazhan N, Zelena D
Brain Research Bulletin (2013 Jun;95:46-53.)
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The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice. Csolle C, Ando RD, Kittel A, Goloncser F, Baranyi M, Soproni K, Zelena D, Haller J, Nemeth T, Mocsai A, Sperlagh B
International Journal of Neuropsychopharmacology (2013 Feb;16(1):213-33.)
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Does chronic stress enhance the risk of diseases? Filaretova L, Morozova O, Laszlo F, Morschl E, Zelena D
Endocrine Regulations (2013 Oct;47(4):177-88.)
PubMed
Blunted HPA axis response in lactating, vasopressin-deficient Brattleboro rats. Fodor A, Pintér O, Domokos A, Langnäse K, Barna I, Engelmann M, Zelena D
Journal of Endocrinology (2013 Oct 4;219(2):89-100.)
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Role of ionotropic glutamate receptors in the control of prolactin secretion by other neurotransmitters and neuropeptides at the level of the pituitary. Jain SK, Zelena D
Endocrine Regulations (2013 Apr;47(2):65-74.)
PubMed
Comparison of Stress-Induced Changes in Adults and Pups: Is Aldosterone the Main Adrenocortical Stress Hormone during the Perinatal Period in Rats? Varga J, Ferenczi S, Kovacs KJ, Garafova A, Jezova D, Zelena D
PLoS One (2013 Sep 5;8(9):e72313.)
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Oxytocin in Brattleboro rats: increased synthesis is contrasted by blunted intrahypothalamic release from supraoptic nucleus neurones. Zelena D, Pinter O, Langnaese K, Richter K, Landgraf R, Makara GB, Engelmann M
Journal of Neuroendocrinology (2013 Aug;25(8):711-8.)
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2012
Estradiol Acts Directly and Indirectly on Multiple Signaling Pathways to Phosphorylate cAMP-Response Element Binding Protein in GnRH Neurons. Cheong RY, Kwakowsky A, Barad Z, Porteous R, Herbison AE, Abraham IM
Endocrinology (2012 Aug;153(8):3792-803.)
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Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB). Kovacs G, Montalbetti N, Simonin A, Danko T, Balazs B, Zsembery A, Hediger MA
Cell Calcium (2012 Dec;52(6):468-80.)
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The biochemical complexity of the endocannabinoid system with some remarks on stress and related disorders: a minireview. Barna I, Zelena D
Endocrine Regulations (2012 Apr;46(2):107-24.)
PubMed
Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress. Derks NM, Pinter O, Zuure W, Ledent C, Watanabe M, Molnar CS, Wei Y, Roubos EW, Wu S, Hrabovszky E, Zelena D, Kozicz T
Journal of Neuroendocrinology (2012 Nov;24(11):1447-61.)
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Maternal neglect with reduced depressive-like behavior and blunted c-fos activation in Brattleboro mothers, the role of central vasopressin. Fodor A, Klausz B, Pinter O, Daviu N, Rabasa C, Rotllant D, Balazsfi D, Kovacs KB, Nadal R, Zelena D
Hormones and Behavior (2012 Sep;62(4):539-51.)
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Nesfatin-1 exerts long-term effect on food intake and body temperature. Konczol K, Pinter O, Ferenczi S, Varga J, Kovacs K, Palkovits M, Zelena D, Toth ZE
International Journal of Obesity (2012 Dec;36(12):1514-21.)
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The vasopressin-deficient Brattleboro rat: lessons for the hypothalamo-pituitary-adrenal axis regulation. Makara GB, Varga J, Barna I, Pinter O, Klausz B, Zelena D
Cellular and Molecular Neurobiology ( 2012 Jul;32(5):759-66.)
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Vasopressin in health and disease with a focus on affective disorders. Zelena D
Central Nervous System Agents in Medicinal Chemistry (2012 Dec;12(4):286-303.)
PubMed
Effect of ageing on post-lesion oestradiol treatment on mouse cholinergic neurones in vivo. Kőszegi Z, Abrahám IM
Journal of Neuroendocrinology ( 2012 Sep;24(9):1243-8.)
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The Role of cAMP Response Element Binding Protein in Estrogen Negative Feedback Control of Gonadotropin-Releasing Hormone Neurons. Kwakowsly A, Herbsion AE, Ábraham IM
Journal of Neuroscience ( 2012 Aug 15;32(33):11309-17.)
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2010
Estrogen augments the T cell-dependent but not the T-independent immune response. Adori M, Kiss E, Barad Zs, Barabás K, Kiszely E, Schneider A, Kövesdi D, Sziksz E, Abraham IM, Matkó J, Sármay G
Cellular and Molecular Life Sciences (2010 May;67(10):1661-74.)
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Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. Keimpema E, Barabas K, Morozov YM, Tortoriello G, Torii M, Cameron G, Yanagawa Y, Watanabe M, Mackie K, Harkany T .
Journal of Neuroscience (2010 Oct 20;30(42):13992-4007.)
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